4,6-Dichloropyrimidine → 6-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

HRID 1846428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846428
[NH2:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[Cl:13][C:14]1[CH:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=1>C(O)CCC>[Cl:13][C:14]1[N:15]=[CH:16][N:17]=[C:18]([NH:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:19]=1

Komponenten

4

Edukt 2

HCID 709434,6-DichloropyrimidineHCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

Produkt 1

HCID 866638946-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

400 mg (2.40 mmol) 6-amino-4-methyl-3H-benzoxazol-2-one, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.10 mL (8.00 mmol) TEA in 5 mL 1-butanol were stirred for 1 h at 100° C. After cooling to RT the reaction mixture was evaporated down and the residue was washed with water and saturated sodium hydrogen carbonate solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

Aufarbeitung

  1. customwas evaporated down
  2. washthe residue was washed with water and saturated sodium hydrogen carbonate solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-ea34a53c021d48cf9ce0601b0b40583a
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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