4,6-Diiodopyrimidine → (6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

HRID 1846440Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846440
Cl.[CH3:2][N:3]1[C:7]2[C:8]([CH3:13])=[CH:9][C:10]([NH2:12])=[CH:11][C:6]=2[N:5]=[C:4]1[CH3:14].[I:15][C:16]1[CH:21]=[C:20](I)[N:19]=[CH:18][N:17]=1>C(O)CCC>[I:15][C:16]1[N:17]=[CH:18][N:19]=[C:20]([NH:12][C:10]2[CH:9]=[C:8]([CH3:13])[C:7]3[N:3]([CH3:2])[C:4]([CH3:14])=[N:5][C:6]=3[CH:11]=2)[CH:21]=1

Komponenten

4

Edukt 2

HCID 157602954,6-DiiodopyrimidineHCID 669781471,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride

Produkt 1

HCID 86663900(6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

150 mg (0.700 mmol) 1,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride, 260 mg (0.800 mmol) 4,6-diiodopyrimidine, 0.300 mL (2.00 mmol) TEA and 5.0 mL 1-butanol were combined and stirred for 1 h at RT. The reaction mixture was evaporated down and the residue was extracted with DCM and 1N aqueous sodium hydroxide solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

Aufarbeitung

  1. customThe reaction mixture was evaporated down
  2. extractionthe residue was extracted with DCM and 1N aqueous sodium hydroxide solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-bfcbd8a1236646ef9474dec19935d0ea
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

Notizen zur Reaktion

Wird geladen…