4-Acetylamino-3-methyl-5-nitro-phenyl acetate → 4-Amino-3-methyl-5-nitrophenol

HRID 1846451Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846451
C([O:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([NH:14]C(=O)C)=[C:7]([CH3:18])[CH:6]=1)(=O)C>Cl>[NH2:14][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]([OH:4])=[CH:6][C:7]=1[CH3:18]

Komponenten

3

Edukt 1

HCID 669782344-Acetylamino-3-methyl-5-nitro-phenyl acetate

Produkt 1

HCID 669782964-Amino-3-methyl-5-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

20.4 g (80.7 mmol) 4-acetylamino-3-methyl-5-nitro-phenyl acetate in 100 mL semi-concentrated aqueous hydrochloric acid were refluxed for 2 h. Then the reaction mixture was evaporated down, the residue was triturated with acetone and suction filtered. After washing with acetone and diethyl ether the precipitate was dried under HV. The mother liquor was evaporated down, the residue was taken up in water and freeze-dried.

Aufarbeitung

  1. customThen the reaction mixture was evaporated down
  2. customthe residue was triturated with acetone and suction
  3. filtrationfiltered
  4. washAfter washing with acetone and diethyl ether the precipitate
  5. customwas dried under HV
  6. customThe mother liquor was evaporated down
  7. customfreeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-1537f24eb5eb4816a570794d73224cec
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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