Potassium Carbonate → 6-(6-chloropyrimidin-4-yloxy)-2-cyclopropyl-4-methyl-1H-benzo[d]imidazole

HRID 1846470Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846470
[CH:1]1([C:4]2[NH:8][C:7]3[CH:9]=[C:10]([OH:14])[CH:11]=[C:12]([CH3:13])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1.[Cl:15][C:16]1[CH:21]=[C:20](Cl)[N:19]=[CH:18][N:17]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][C:16]1[N:17]=[CH:18][N:19]=[C:20]([O:14][C:10]2[CH:11]=[C:12]([CH3:13])[C:6]3[N:5]=[C:4]([CH:1]4[CH2:3][CH2:2]4)[NH:8][C:7]=3[CH:9]=2)[CH:21]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669781752-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol

Produkt 1

HCID 866639156-(6-chloropyrimidin-4-yloxy)-2-cyclopropyl-4-methyl-1H-benzo[d]imidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

90 mg (0.48 mmol) 2-cyclopropyl-4-methyl-1H-benzo[d]imidazol-6-ol and 77 mg (0.50 mmol) 4,6-dichloropyrimidine in 2.0 mL DMF were combined with 70 mg (0.50 mmol) potassium carbonate and stirred for 8 h at 50° C. Then ice water was added and the substance was extracted with ethyl acetate and concentrated by rotary evaporation i.vac.

Aufarbeitung

  1. extractionthe substance was extracted with ethyl acetate
  2. concentrationconcentrated by rotary evaporation i.vac

Quellen und Nachweise

ORD-Eintrag
ord-ba3817d0dbdd4efc92385480aebc5827
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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