Azidotrimethylsilane → 2-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-quinolin-8-ol

HRID 18467

Reaktionsgleichung

Reaktionsgleichung von HRID 18467
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[N:19]=[C:18]([CH:21]=O)[CH:17]=[CH:16]2.C[Si]([N:27]=[N+:28]=[N-:29])(C)C.[N+:30]([CH2:32][C:33]([CH3:36])([CH3:35])[CH3:34])#[C-:31]>CO>[CH3:34][C:33]([CH3:36])([CH3:35])[CH2:32][N:30]1[C:31]([CH:21]([NH:9][CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:18]2[CH:17]=[CH:16][C:15]3[C:20](=[C:11]([OH:10])[CH:12]=[CH:13][CH:14]=3)[N:19]=2)=[N:29][N:28]=[N:27]1

Komponenten

6

Edukt 4

HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 5993428-Hydroxy-2-quinolinecarboxaldehydeHCID 27586461-Isocyano-2,2-dimethyl-propane

Produkt 1

HCID 250606942-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-quinolin-8-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Imidazol-1-yl-propylamine (1 mmol) and 8-Hydroxy-quinoline-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Isocyano-2,2-dimethyl-propane (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Aufarbeitung

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Quellen und Nachweise

ORD-Eintrag
ord-3470187e804f4bbabac598a8116168a6
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741354B2

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