3-Benzyloxycyclobutane-1,1-dicarboxylic acid → 3-(Benzyloxy)cyclobutane-1-carboxylic acid

HRID 1846753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846753
[CH2:1]([O:8][CH:9]1[CH2:12][C:11](C(O)=O)([C:13]([OH:15])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N1C=CC=CC=1>[CH2:1]([O:8][CH:9]1[CH2:10][CH:11]([C:13]([OH:15])=[O:14])[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 6387653-Benzyloxycyclobutane-1,1-dicarboxylic acid

Produkt 1

HCID 128151113-(Benzyloxy)cyclobutane-1-carboxylic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (1.5 g, 5.99 mmol) in pyridine (3 mL) was heated in a 120° C. oil bath for 12 h. The mixture was cooled to RT and the pyridine was removed under vacuum. Toluene (10 mL) was added and the solution was washed with 1N HCl (3×), dried (MgSO4), filtered, and concentrated in vacuo to give product as a brown oil (1.17 g, 95%).

Aufarbeitung

  1. customthe pyridine was removed under vacuum
  2. additionToluene (10 mL) was added
  3. washthe solution was washed with 1N HCl (3×)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-161fb393cbd24dc28f77b7822cf23a18
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952037B2

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