Potassium Carbonate → 6-(Methyloxy)-4-{2-[(2S)-2-oxiranyl]ethyl}pyrido[2,3-b]pyrazin-3(4H)-one
Reaktionsgleichung
CC1C=CC(S(O[CH2:12][C@@H:13]([OH:29])[CH2:14][CH2:15][N:16]2[C:21](=[O:22])[CH:20]=[N:19][C:18]3[CH:23]=[CH:24][C:25]([O:27][CH3:28])=[N:26][C:17]2=3)(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:28][O:27][C:25]1[CH:24]=[CH:23][C:18]2[N:19]=[CH:20][C:21](=[O:22])[N:16]([CH2:15][CH2:14][C@H:13]3[CH2:12][O:29]3)[C:17]=2[N:26]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In methanol (15 ml) was dissolved (2S)-2-hydroxy-4-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)butyl 4-methylbenzenesulfonate (227 mg, 0.540 mmol), and potassium carbonate (90 mg, 0.648 mmol) was then added to the solution at room temperature. The obtained mixture was stirred for 17 hours. Thereafter, the solvent was removed from the reaction solution under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform/methanol) to yield 83 mg (62%) of the above-captioned compound in the form of a yellow solid.