2H-Pyran-3(4H)-one, dihydro- → 3-(2,4,5-Trifluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

HRID 18477

Reaktionsgleichung

Reaktionsgleichung von HRID 18477
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]3[CH2:14]N(C(OC(C)(C)C)=O)C[CH2:17][C:12]=3[NH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].O1CCC[C:27](=[O:31])C1.[F:32]C1C=C(F)C(F)=CC=1C(Cl)=O>>[F:32][C:5]1[CH:6]=[C:7]([F:8])[C:2]([F:1])=[CH:3][C:4]=1[C:9]1[C:13]2[CH2:14][CH2:27][O:31][CH2:17][C:12]=2[NH:11][N:10]=1

Komponenten

4

Edukt 3

HCID 901092H-Pyran-3(4H)-one, dihydro-HCID 1451642,4,5-Trifluorobenzoyl chlorideHCID 59345327tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

Produkt 1

HCID 593453423-(2,4,5-Trifluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

Versuchsvorschrift

Intermediate 16D was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one, and replacing 3,4-difluorobenzoyl chloride with 2,4,5-trifluorobenzoyl chloride. LCMS (+ESI) m/z=255 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-36dedcaa54664e099a65833376c16631
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741350B1

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