Reaktionsgleichung
[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[OH-].[OH-].[Pd+2].O1CCOCC1>[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][CH2:9][NH:10][C:11]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A 2 L round bottom flask equipped with a stir bar was charged with a suspension of 20% Pd(OH)2 (5 g) and 1,4-dioxane (800 mL). [2-(5-Methoxy-2-nitrophenylamino)-ethyl]-carbamic acid tert-butyl ester (10 g, 0.32 mol) was added to the suspension. The reaction mixture was hydrogenated (balloon) for 48 h (until the starting material had been consumed) followed by the addition of K2CO3 (10 g) was added to the mixture and stirred for an additional 12 h to remove traces of water. The suspension was filtered to remove the Pd(OH)2 and K2CO3. The filtrate was used in the next step without further purification (yield not determined).
Aufarbeitung
- customA 2 L round bottom flask equipped with a stir bar
- customfor 48 h
- customhad been consumed)
- additionfollowed by the addition of K2CO3 (10 g)
- additionwas added to the mixture
- customto remove traces of water
- filtrationThe suspension was filtered
- customto remove the Pd(OH)2 and K2CO3
- customThe filtrate was used in the next step without further purification (
- customyield not
Quellen und Nachweise
- ORD-Eintrag
- ord-9c95abcced5242e6bb2fa54e2244b5aa
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07741355B2
Verknüpfte Notizen
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