5-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid → Tert-butyl 5-chloro-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

HRID 1849639Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1849639
ClC1C(OCC2(C(F)(F)F)CCCCC2)=C[C:5](F)=[C:6]([CH:10]=1)[C:7](O)=O.[Cl:24][C:25]1[C:26]([O:35][CH2:36][CH:37]2[CH2:42][CH2:41][CH2:40][C:39]([CH3:44])([CH3:43])[CH2:38]2)=[CH:27][C:28]([F:34])=[C:29]([CH:33]=1)[C:30]([OH:32])=[O:31]>>[Cl:24][C:25]1[C:26]([O:35][CH2:36][CH:37]2[CH2:42][CH2:41][CH2:40][C:39]([CH3:44])([CH3:43])[CH2:38]2)=[CH:27][C:28]([F:34])=[C:29]([CH:33]=1)[C:30]([O:32][C:6]([CH3:10])([CH3:7])[CH3:5])=[O:31]

Komponenten

3

Edukt 2

HCID 867034465-Chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acidHCID 867035005-Chloro-4-((3,3-dimethylcyclohexyl)methoxy)-2-fluorobenzoic acid

Produkt 1

HCID 86703499Tert-butyl 5-chloro-4-((3,3-dimethylcyclohexyl)-methoxy)-2-fluorobenzoate

Versuchsvorschrift

Following the procedure as described in Example 158 step 2 and making variations as required to replace 5-chloro-2-fluoro-4-((1-(trifluoromethyl)cyclohexyl)methoxy)benzoic acid with 5-chloro-4-((3,3-dimethylcyclohexyl)methoxy)-2-fluorobenzoic acid, the title compound was obtained as pale yellow oil (3.20 g, 99%): MS (ES−) m/z 316.9 (M−54).

Quellen und Nachweise

ORD-Eintrag
ord-bf175a0958c24efba7749eb780e01d6b
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952169B2

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