Methyl 5-chloro-4-((4,4-difluorocyclohexyl)oxy)-2-fluorobenzoate → 5-Cyclopropyl-2-fluoro-4-(spiro[2.5]octan-6-yloxy)benzoic acid
Reaktionsgleichung
ClC1C(OC2CCC(F)(F)CC2)=CC(F)=C(C=1)C(OC)=O.[CH:22]1([C:25]2[C:26]([O:36][CH:37]3[CH2:44][CH2:43][C:40]4([CH2:42][CH2:41]4)[CH2:39][CH2:38]3)=[CH:27][C:28]([F:35])=[C:29]([CH:34]=2)[C:30]([O:32]C)=[O:31])[CH2:24][CH2:23]1>>[CH:22]1([C:25]2[C:26]([O:36][CH:37]3[CH2:44][CH2:43][C:40]4([CH2:41][CH2:42]4)[CH2:39][CH2:38]3)=[CH:27][C:28]([F:35])=[C:29]([CH:34]=2)[C:30]([OH:32])=[O:31])[CH2:24][CH2:23]1Komponenten
3
Versuchsvorschrift
Following the procedure as described in Example 357 Step 6 and making non-critical variations to replace methyl 5-chloro-4-((4,4-difluorocyclohexyl)oxy)-2-fluorobenzoate with methyl 5-cyclopropyl-2-fluoro-4-(spiro[2.5]octan-6-yloxy)benzoate, the title compound was obtained as a colorless syrup that was carried forward without further purification (0.393 g, quant. yield).
Quellen und Nachweise
- ORD-Eintrag