Hydrochloride methanol → [1-(3-Azetidin-3-YL-pyrazin-2-YL)-piperidin-4-YL]-methanol hydrochloride
Reaktionsgleichung
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[NH:8]1[CH2:11][CH:10]([C:12]2[C:17]([N:18]3[CH2:23][CH2:22][CH:21]([CH2:24][OH:25])[CH2:20][CH2:19]3)=[N:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1Komponenten
3
Versuchsvorschrift
A solution of (36) (557 mg, 1.6 mmol) in 4N HCl/MeOH (20 mL) was stirred at RT for 30 min. The reaction mixture was concentrated to give (37) (450 mg, 1.58 mmol, yield 98%).
Aufarbeitung
- concentrationThe reaction mixture was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-b6cc3478763440b485420695ef72acb5