1-Methyl-1H-imidazol-2-amine → 1-(1-methyl-1H-imidazole-2-yl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

HRID 1850505Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1850505
Cl[CH2:2][CH2:3][N:4]([CH2:19][CH2:20]Cl)[C:5]1[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[C:15]=1[CH3:16].[CH3:22][N:23]1[CH:27]=[CH:26][N:25]=[C:24]1[NH2:28]>>[CH3:22][N:23]1[CH:27]=[CH:26][N:25]=[C:24]1[N:28]1[CH2:20][CH2:19][N:4]([C:5]2[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]3[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 5663211-Methyl-1H-imidazol-2-amineHCID 66760837N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine

Produkt 1

HCID 594850741-(1-methyl-1H-imidazole-2-yl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazineAusbeute 51,9 %

Versuchsvorschrift

By using N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine (330 mg, 1.0 mmol) synthesized in Reference Example 146 and 1-methyl-1H-imidazole-2-amine (146 mg, 1.5 mmol), the reaction was carried out in the same manner as Example 117 to obtain 184 mg of the title compound as an oily product (yield 52%).

Quellen und Nachweise

ORD-Eintrag
ord-165922782e7448b5aad03781db869b3f
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957069B2

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