tert-Butyl (1-isopropylpiperidin-4-yl)carbamate → 1-(Propan-2-yl)piperidin-4-amine

HRID 18506

Reaktionsgleichung

Reaktionsgleichung von HRID 18506
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]1)(C)(C)C>CO.Cl>[CH:14]([N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:16])[CH3:15]

Komponenten

4

Edukt 1

HCID 20801240tert-Butyl (1-isopropylpiperidin-4-yl)carbamate

Produkt 1

HCID 31633331-(Propan-2-yl)piperidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 4.8 g (1-Isopropyl-piperidin-4-yl)-carbamic acid tert-butyl ester in 15 mL methanol, 20 mL methanolic hydrochloric acid (8 M) were added and the mixture was stirred for 16 h. Removal of the solvent under reduced pressure, followed by removal of residual volatiles by twice coevaporating with toluene, gave the product. Yield: 5.42 g MS (ES+): m/e=143.

Aufarbeitung

  1. customRemoval of the solvent under reduced pressure
  2. customfollowed by removal of residual volatiles
  3. customgave the product

Quellen und Nachweise

ORD-Eintrag
ord-6fa2e1b0db5b4502a6fba40fd57bed62
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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