2-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide → 2-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

HRID 1850724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1850724
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])=[C:11]([CH3:21])[CH:10]=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([N:18]([CH3:19])[CH3:20])=[O:17])=[C:11]([CH3:21])[CH:10]=1

Komponenten

4

Edukt 1

HCID 708189752-(4-(benzyloxy)-2-methylphenyl)-N,N-dimethylacetamide

Produkt 1

HCID 867111812-(4-hydroxy-2-methylphenyl)-N,N-dimethylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-[4-(benzyloxy)-2-methylphenyl]-N,N-dimethylacetamide (680 mg, 2.40 mmol) was dissolved in ethanol (4 ml). and palladium hydroxide on carbon (20%) (169 mg, 0.240 mmol) added. The mixture was stirred under an atmosphere of hydrogen gas at RT overnight. The mixture was filtered and the filtrate concentrated under reduced pressure to afford the title compound. LC/MS (m/z): 194 (M+H)+.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7ceebfc211ed427399250b59d1f9e844
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957062B2

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