1-(p-Chlorophenyl)cyclobutanecarboxylic acid → 2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine

HRID 1850844

Reaktionsgleichung

Reaktionsgleichung von HRID 1850844
FC1C=CC(C2([C:12]3C4C(=CC=C(OCCN)C=4)CC[N:13]=3)CCC2)=CC=1.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]([CH3:38])([CH3:37])[CH2:35][NH2:36])=[CH:30][CH:29]=1.[Cl:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2([C:50](O)=O)[CH2:49][CH2:48][CH2:47]2)=[CH:42][CH:41]=1.FC1C=CC(C2(C(O)=O)CCC2)=CC=1>>[Cl:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2([C:50]3[C:32]4[C:31](=[CH:30][CH:29]=[C:28]([O:27][CH2:26][CH2:12][NH2:13])[CH:33]=4)[C:34]([CH3:38])([CH3:37])[CH2:35][N:36]=3)[CH2:49][CH2:48][CH2:47]2)=[CH:42][CH:41]=1

Komponenten

5

Edukt 4

HCID 6027611-(p-Chlorophenyl)cyclobutanecarboxylic acidHCID 35813642-(4-Methoxyphenyl)-2-methylpropan-1-amineHCID 167690171-(4-Fluorophenyl)cyclobutanecarboxylic acidHCID 582463242-({1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine

Produkt 1

HCID 582463022-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine

Versuchsvorschrift

2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine was prepared analogously to 2-({1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine (cf. example 65) using 2-(4-methoxyphenyl)-2-methylpropan-1-amine and 1-(4-chlorophenyl)cyclobutanecarboxylic acid in place of 2-(4-methoxyphenyl)ethanamine and 1-(4-fluorophenyl)cyclobutanecarboxylic acid, respectively.

Quellen und Nachweise

ORD-Eintrag
ord-6e8e71afa12b4646a18c76613196a50f
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957089B2

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