2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine → N-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide hydrochloride

HRID 1850845

Reaktionsgleichung

Reaktionsgleichung von HRID 1850845
Cl.FC1C=CC(C2(C3C4C(=CC=C(OCCN[S:27]([CH2:30][CH2:31][CH3:32])(=[O:29])=[O:28])C=4)CCN3)CCC2)=CC=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2([C:44]3[C:53]4[C:48](=[CH:49][CH:50]=[C:51]([O:54][CH2:55][CH2:56][NH2:57])[CH:52]=4)[C:47]([CH3:59])([CH3:58])[CH2:46][N:45]=3)[CH2:43][CH2:42][CH2:41]2)=[CH:36][CH:35]=1>>[ClH:33].[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2([CH:44]3[C:53]4[C:48](=[CH:49][CH:50]=[C:51]([O:54][CH2:55][CH2:56][NH:57][S:27]([CH2:30][CH2:31][CH3:32])(=[O:29])=[O:28])[CH:52]=4)[C:47]([CH3:59])([CH3:58])[CH2:46][NH:45]3)[CH2:43][CH2:42][CH2:41]2)=[CH:36][CH:35]=1

Komponenten

3

Edukt 2

HCID 582463022-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamineHCID 66868755N-[2-({1-[1-(4-fluorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide hydrochloride

Produkt 1

HCID 66868673N-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide hydrochloride

Versuchsvorschrift

N-[2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide hydrochloride was prepared analogously to N-[2-({1-[1-(4-fluorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)ethyl]propane-1-sulfonamide hydrochloride (cf. example 65) using 2-({1-[1-(4-chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine in place of 2-({1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine.

Quellen und Nachweise

ORD-Eintrag
ord-28f3bc00dc9d4195aae081e453720169
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957089B2

Verknüpfte Notizen

Wird geladen…