2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178478263, Verbindung

HRID 1851257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1851257
[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 867030314-(3-Chloro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Produkt 1

HCID 178478263HCID 178478263, VerbindungAusbeute 52 %

Versuchsvorschrift

200 mg (0.6 mmol) 4-(3-chloro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde was reacted with 197 mg (0.72 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 162 mg of the desired product were obtained

Aufarbeitung

  1. waitAfter four and a half hours the reaction mixture was worked up
  2. custompurified in the usual way

Quellen und Nachweise

ORD-Eintrag
ord-7b93f7db50ed499ca6584dffa99ba29b
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957064B2

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