HCID 57901756, Verbindung → HCID 57901650, Verbindung

HRID 1851456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1851456
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:15])=[O:14]>[O-2].[O-2].[Mn+4].O1CCCC1>[CH:2]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:14])=[O:15])=[O:1]

Komponenten

4

Edukt 1

HCID 57901756HCID 57901756, Verbindung

Produkt 1

HCID 57901650HCID 57901650, VerbindungAusbeute 9,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of N-[2-(hydroxymethyl)-1H-indol-7-yl]thiophene-2-sulfonamide (1.30 g), activated manganese dioxide (8.0 g) and tetrahydrofuran (30 mL) was stirred at room temperature for 5 hr. The reaction mixture was filtrated, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and the title compound (0.12 g, yield 9%) was obtained as yellow crystals from a fraction eluted with tetrahydrofuran-hexane (2:1, volume ratio). melting point>226° C. (decomposition).

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-f79df25f89af4b9981d28e12c5604138
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957070B2

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