Ethanol → Carfentrazone-ethyl

HRID 1851699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1851699
[Cl:1][CH:2]([CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[C:17](=[O:18])[N:16]([CH:19]([F:21])[F:20])[C:15]([CH3:22])=[N:14]2)[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])[C:3]([OH:5])=[O:4].[CH2:25](O)[CH3:26]>C1C=CC=CC=1>[CH3:25][CH2:26][O:4][C:3]([CH:2]([Cl:1])[CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[N:14]=[C:15]([CH3:22])[N:16]([CH:19]([F:20])[F:21])[C:17]2=[O:18])[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])=[O:5]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 443229Carfentrazone

Produkt 1

HCID 86222Carfentrazone-ethyl

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

adding 1 mol of the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propionic acid of the step (1), 4˜10 mol of ethanol and 0.03˜0.2 mol of an acid catalyst into 6˜12 mol of the solvent of benzene class; refluxing the reaction mixture until an esterification is completed; washing successively with water, with aqueous alkali base and then with water; and removing the solvent totally from the organic layer, to give the product carfentrazone-ethyl;

Aufarbeitung

  1. temperaturerefluxing the reaction mixture until an esterification
  2. washwashing successively with water, with aqueous alkali base
  3. customand removing the solvent totally from the organic layer

Quellen und Nachweise

ORD-Eintrag
ord-455c6651ff834c9b8d298133bb6c6606
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957220B2

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