m-Chloroperbenzoic acid → 4-Methylisoquinoline 2-oxide

HRID 1852210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852210
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N+:4]([O-:20])[CH:3]=1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 640939Isoquinoline, 4-methyl-

Produkt 1

HCID 229588294-Methylisoquinoline 2-oxideAusbeute 97,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 4-methylisoquinoline (0.6 g, 4.19 mmol) in DCM (20 ml) was added m-CPBA (2.169 g, 12.57 mmol) at room temperature. The reaction mass was stirred at the same temperature for 18 h. The reaction mass was diluted with DCM and extracted with water. The combined organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get desired compound (0.65 g, 88%) as a semi solid. The crude compound was taken further without purification.

Aufarbeitung

  1. extractionextracted with water
  2. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-68095ebeb1fb41e9beb633b3a4ec0292
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957203B2

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