Heptane → HCID 54684579, Verbindung

HRID 1852413Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1852413
C[N:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:3]([C:5]1[C:6](=[O:17])[N:7]([CH3:16])[C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[F:24]C1C=CC(N)=CC=1.CCCCCCC>C1(C)C=CC=CC=1>[F:24][C:21]1[CH:22]=[CH:23][C:18]([NH:2][C:3]([C:5]2[C:6](=[O:17])[N:7]([CH3:16])[C:8]3[C:13]([C:14]=2[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=3)=[O:4])=[CH:19][CH:20]=1

Komponenten

5

Edukt 3

HCID 8900HeptaneHCID 97314-FluoroanilineHCID 54676478Roquinimex

Produkt 1

HCID 54684579HCID 54684579, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of N-methyl-N-phenyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide (15 mg, 0.050 mmol) and 4-fluoro-aniline (0.100 mmol) in toluene (0.5 mL) was stirred at 100° C. for 1 h. Heptane (1.5 mL) was added and the solution was allowed to cool to room temperature. The crystallized product was separated from the solution and washed with heptane to give the title compound (12 mg, 79%).

Aufarbeitung

  1. customThe crystallized product was separated from the solution
  2. washwashed with heptane

Quellen und Nachweise

ORD-Eintrag
ord-be9d88eac4554872b56850416c322980
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962598B2

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