Methyl 2-acetamidoacrylate → Methyl 7-chloroisoquinoline-3-carboxylate
Reaktionsgleichung
Br[C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.C([NH:14][C:15](=[CH2:20])[C:16]([O:18][CH3:19])=[O:17])(=O)C>>[Cl:10][C:7]1[CH:6]=[C:3]2[C:2]([CH:20]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[N:14]=[CH:4]2)=[CH:9][CH:8]=1Komponenten
3
Versuchsvorschrift
methyl 7-chloro-isoquinoline-3-carboxylate was prepared using the procedure described in example 12A: 2-bromo-5-chlorobenzaldehyde was reacted with methyl 2-acetamidoacrylate at 110° C. for 24 hours to yield methyl 7-chloro-isoquinoline-3-carboxylate (25%) as brown solid.
Aufarbeitung
- custommethyl 7-chloro-isoquinoline-3-carboxylate was prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-ffda6479c38f4da3a4e42b85c693c17d
- Quelldatensatz
- uspto-grants-2015_02
- Patentnummer
- US08962627B2
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