Divinyl sulfone → [4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

HRID 18537

Reaktionsgleichung

Reaktionsgleichung von HRID 18537
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH:16]([S:18]([CH:21]=[CH2:22])(=[O:20])=[O:19])=[CH2:17]>CCO>[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:22][CH2:21][S:18](=[O:20])(=[O:19])[CH2:16][CH2:17]2)=[CH:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 6496Divinyl sulfoneHCID 688611tert-Butyl (4-aminophenyl)carbamate

Produkt 1

HCID 68616091[4-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-phenyl]-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 408 mg (4-Amino-phenyl)-carbamic acid tert-butyl ester and 254 mg Ethenesulfonyl-ethene in 4 mL EtOH were heated for 30 min at 140° C. under microwave irradiation (100 W, CEM Discover™ apparatus). Then, after cooling to RT the solvents were removed under reduced pressure and the residue was dried in vacuo. The crude product was subjected to the next reaction step.

Aufarbeitung

  1. customwere removed under reduced pressure
  2. customthe residue was dried in vacuo
  3. customThe crude product was subjected to the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-770f859b938246188dc93593dd1d1dc5
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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