Boron tribromide → HCID 86689482, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[C:11]2[NH:10][C:9](=[O:12])[C:8]3[S:13][CH:14]=[CH:15][C:7]=3[C:6]=2[C:5]([C:16]2[CH:31]=[CH:30][C:19]([CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C)=[CH:18][CH:17]=2)=[C:4]([O:32]C)[CH:3]=1.B(Br)(Br)[Br:35]>>[ClH:1].[NH2:22][CH2:21][CH2:20][C:19]1[CH:30]=[CH:31][C:16]([C:5]2[C:6]3[C:7]4[CH:15]=[CH:14][S:13][C:8]=4[C:9](=[O:12])[NH:10][C:11]=3[C:2]([Br:35])=[CH:3][C:4]=2[OH:32])=[CH:17][CH:18]=1Komponenten
3
Versuchsvorschrift
Following General Procedure F, tert-butyl 4-(6-chloro-8-methoxy-4-oxo-4,5-dihydrothieno[2,3-c]quinolin-9-yl)phenethylcarbamate (410 mg, 0.76 mmol) was treated with BBr3 (1.0 M in CH2Cl2, 10 mL, 10 mmol) to afford the desired product as an off-white solid (58 mg, 18%): 1H NMR (500 MHz, CD3OD) δ 7.62 (d, J=5.4 Hz, 1H), 7.53-7.45 (m, 3H), 7.31 (d, J=8.1 Hz, 2H), 6.10 (d, J=5.4 Hz, 1H), 3.31-3.28 (m, 2H), 3.11 (t, J=7.6 Hz, 2H); ESI MS m/z 415 [C19H15BrN2O2S+H]+; HPLC 94.9% (AUC), tR=9.02 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-b83f838a79004363aa2a2385b9a84def
- Quelldatensatz
- uspto-grants-2015_02