Borane;tetrahydrofuran → 1-[1-(4-Bromophenyl)cyclopropyl]methanamine

HRID 1853915Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1853915
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.B.C1COCC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:11][NH2:12])[CH2:9][CH2:10]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 2723981Borane;tetrahydrofuranHCID 27952731-(4-Bromophenyl)Cyclopropanecarbonitrile

Produkt 1

HCID 289378461-[1-(4-Bromophenyl)cyclopropyl]methanamineAusbeute 94 %

Versuchsvorschrift

Following the procedure outlined for Example 666, 1-(4-bromophenyl)cyclopropane carbonitrile (2.0 g, 9.0 mmol) was reacted with BH3.THF (1.0 M in THF, 50 mL, 50 mmol) to afford the desired product (1.9 g, 94%) as a yellow oil: ESI MS m/z 226 [C10H12BrN+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-dd0fd6b6bd85428abd2f8032c04c1d81
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962648B2

Notizen zur Reaktion

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