Ammonia → 1-(4-Aminophenyl)piperazin-2-one

HRID 18540Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 18540
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]2=[O:16])=[CH:6][CH:5]=1)([O-])=O.N.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]2=[O:16])=[CH:8][CH:9]=1

Komponenten

6

Edukt 3

HCID 222AmmoniaHCID 23086769HCID 23086769, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 534061751-(4-Aminophenyl)piperazin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a solution of 670 mg 1-(4-Nitro-phenyl)-1H-pyrazin-2-one in 100 mL MeOH, 8 g Raney Nickel (washed three times with MeOH) were introduced under a nitrogen atmosphere. Then 10 mL of a 7 M solution of NH3 in MeOH were added. The nitrogen atmosphere was replaced by a hydrogen atmosphere and the mixture was hydrogenated under normal pressure at RT. After 2 h the reaction mixture was filtered through a pad of celite. The solvents were removed under reduced pressure and the residue was subjected to the next reaction step without further purification.

Aufarbeitung

  1. customwas hydrogenated under normal pressure at RT
  2. filtrationAfter 2 h the reaction mixture was filtered through a pad of celite
  3. customThe solvents were removed under reduced pressure
  4. customthe residue was subjected to the next reaction step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c83c3cd7ec4f44a284775955b7ce9cbc
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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