Nitric Acid → 2-Methyl-3-nitro-5-(trifluoromethyl)benzoic acid

HRID 1854147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1854147
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:15]([O-])([OH:17])=[O:16]>OS(O)(=O)=O>[CH3:1][C:2]1[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:8]([C:11]([F:12])([F:13])[F:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 27755852-Methyl-5-(trifluoromethyl)benzoic acid

Produkt 1

HCID 682955012-Methyl-3-nitro-5-(trifluoromethyl)benzoic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Versuchsvorschrift

A stirred solution of 2-methyl-5-(trifluoromethyl)benzoic acid (1 mmol) in conc. H2SO4 (2 mL) was cooled to −10° C. and a nitrating mixture (0.4 mL of cone. H2SO4+0.1 mL of cone. HNO3) was added to it in dropwise manner. The reaction mixture was stirred at same temperature for 20 min before warming to room temperature. The resulting precipitate was filtered off and dried to obtain 2-methyl-3-nitro-5-(trifluoromethyl)benzoic acid which was used in next step without further purification (yield 60-70%).

Aufarbeitung

  1. filtrationThe resulting precipitate was filtered off
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-884374ea5b504213bac566c402b991cd
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962620B2

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