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Triethylamine → (2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-(3-(2-acetoxyethyl)thioureido)-tetrahydro-2H-pyran-2,4,5-triyl triacetate

HRID 1854252
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Reaktionsgleichung

Reaktionsgleichung von HRID 1854252
[C:1]([O:4][C@H:5]1[C@H:10]([N:11]=[C:12]=[S:13])[C@@H:9]([O:14][C:15](=[O:17])[CH3:16])[C@H:8]([O:18][C:19](=[O:21])[CH3:20])[C@@H:7]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[O:6]1)(=[O:3])[CH3:2].FC(F)(F)C(O)=O.[C:34]([O:37][CH2:38][CH2:39][NH2:40])(=[O:36])[CH3:35].C(N(CC)CC)C>CC#N.C(Cl)Cl>[C:1]([O:4][C@H:5]1[C@H:10]([NH:11][C:12]([NH:40][CH2:39][CH2:38][O:37][C:34](=[O:36])[CH3:35])=[S:13])[C@@H:9]([O:14][C:15](=[O:17])[CH3:16])[C@H:8]([O:18][C:19](=[O:21])[CH3:20])[C@@H:7]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[O:6]1)(=[O:3])[CH3:2]
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Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 14130735(2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-isothiocyanatotetrahydro-2H-pyran-2,4,5-triyl triacetateHCID 873085332-aminoethyl acetate TFA-salt

Produkt 1

HCID 87308604(2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-(3-(2-acetoxyethyl)thioureido)-tetrahydro-2H-pyran-2,4,5-triyl triacetateAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342
Acetonitrile
Lösungsmittel
HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of (2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-isothiocyanato-tetrahydro-2H-pyran-2,4,5-triyl triacetate (500 mg, 1.3 mmol) in CH3CN (10 mL) was added 2-aminoethyl acetate trifluoroacetate (600 mg, 3 mmol) and triethylamine (0.5 mL, 3.5 mmol). The mixture was stirred at room temperature for 1 h. The solution was diluted with CH2Cl2 (50 mL) and washed with saturated aqueous NaHCO3 (20 mL), and the organic extract was dried (Na2SO4) and concentrated. The residue was purified by flash chromatography on silica gel (hexane/EtOAc 1:1) to give (2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-(3-(2-acetoxyethyl)thioureido)-tetrahydro-2H-pyran-2,4,5-triyl triacetate as a white foam (580 mg, 92% yield). 1H NMR (600 MHz, DMSO-d6) δ 2.06 (s, 3H), 2.08 (s, 3H), 2.11 (s, 3H), 2.12 (s, 3H), 2.15 (s, 3H), 3.66-3.80 (m, 2H), 3.85 (ddd, 1H, J=2.5, 4.5, 9.0 Hz), 4.14 (dd, 1H, J=2.0, 12.5 Hz), 4.22 (dd, 1H, J=5.0, 5.0 Hz), 4.29 (dd, 1H, J=4.5, 12.5 Hz), 4.65-4.75 (m, 1H), 5.13-5.22 (m, 2H), 5.73 (d, 1H, J=8.5 Hz).13C NMR (125 MHz, DMSO-d6) δ 20.82, 20.86, 20.98, 21.04, 21.19, 40.51, 57.21, 61.85, 62.75, 68.25, 71.84, 73.12, 92.65, 169.34, 169.73, 170.13, 170.49, 170.77, 184.26.

Aufarbeitung

  1. washwashed with saturated aqueous NaHCO3 (20 mL)
  2. extractionthe organic extract
  3. dry with materialwas dried (Na2SO4)
  4. concentrationconcentrated
  5. customThe residue was purified by flash chromatography on silica gel (hexane/EtOAc 1:1)

Quellen und Nachweise

ORD-Eintrag
ord-58dd4605a8294152ba48276b85944880
Quelldatensatz
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08962664B2

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