Methanol → methyl 4-methylnicotinate

HRID 1854359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1854359
[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][CH:3]=1.OS(O)(=O)=O.[CH3:16]O>>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:16])=[O:9])=[CH:6][N:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2291634-Methylnicotinic acid

Produkt 1

HCID 10877301methyl 4-methylnicotinateAusbeute 94 %

Versuchsvorschrift

A solution of 4-methylnicotinic acid (2.00 g, 14.6 mmol) and concentrated H2SO4 (4.66 mL, 87.6 mmol) in MeOH (50 mL) was heated at about 60° C. for about 16 h. The reaction was concentrated under reduced pressure then partitioned with EtOAc (150 mL) and saturated aqueous NaHCO3 (200 mL). The organic layer was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure to a constant weight to afford methyl 4-methylnicotinate as a clear liquid (2.30 g, 94%): LC/MS (Table 2, Method a) Rt=1.67 min; MS m/z: 152 (M+H)+.

Aufarbeitung

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthen partitioned with EtOAc (150 mL) and saturated aqueous NaHCO3 (200 mL)
  3. dry with materialThe organic layer was dried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure to a constant weight

Quellen und Nachweise

ORD-Eintrag
ord-286200668d944bc286c2bb62d44d5be1
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08962629B2

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