2-(4-Chlorobenzoyl)-3-(dimethylamino)prop-2-enenitrile → HCID 57829800, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8](=[CH:11]N(C)C)[C:9]#[N:10])=O)=[CH:4][CH:3]=1.[N+]([O-])(O)=O.[N+]([O-])(O)=O.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([NH:39][C:40]([NH2:42])=[NH:41])[CH:30]=[CH:31][C:32]=1[N:33]1[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[C:8]([C:9]#[N:10])=[CH:11][N:42]=[C:40]([NH:39][C:29]3[CH:30]=[CH:31][C:32]([N:33]4[CH:37]=[C:36]([CH3:38])[N:35]=[CH:34]4)=[C:27]([O:26][CH3:25])[CH:28]=3)[N:41]=2)=[CH:15][CH:16]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from crude 2-(4-chloro-benzoyl)-3-dimethylamino-acrylonitrile (50 mg, 0.21 mmol) and N-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-guanidine dinitrate (66 mg, 0.18 mmol) using in analogous manner the procedure described in example 28b). Obtained as a pale-yellow solid (10 mg, 14%).
Quellen und Nachweise
- ORD-Eintrag
- ord-2bf8fd84d6284c1c816414152b8b81c3
- Quelldatensatz
- uspto-grants-2015_02