3-(4-Phenylpiperazin-1-yl)propan-1-amine → Methyl 3-(1-diphenylmethylpiperazin-4-ylpropylureido)-isovalerate

HRID 1855746

Reaktionsgleichung

Reaktionsgleichung von HRID 1855746
[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)N2CCN(CCCN)CC2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([N:30]2[CH2:35][CH2:34][N:33]([CH2:36][CH2:37][CH2:38][NH2:39])[CH2:32][CH2:31]2)C=CC=CC=1.[N:40]([C:43]([CH3:50])([CH3:49])[CH2:44][C:45]([O:47][CH3:48])=[O:46])=[C:41]=[O:42]>C1(C)C=CC=CC=1>[C:1]1([CH:7]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:40]([C:43]([CH3:50])([CH3:49])[CH2:44][C:45]([O:47][CH3:48])=[O:46])[C:41]([NH:39][CH2:38][CH2:37][CH2:36][N:33]2[CH2:32][CH2:31][NH:30][CH2:35][CH2:34]2)=[O:42])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 2612973-(4-Phenylpiperazin-1-yl)propan-1-amineHCID 137677783-(4-Benzhydryl-1-piperazinyl)-1-propanamineHCID 15042553Methyl 3-isocyanato-3-methylbutanoate

Produkt 1

HCID 70587116Methyl 3-(1-diphenylmethylpiperazin-4-ylpropylureido)-isovalerate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

9.0 g (0.029 mol) of 1-diphenylmethyl-4-(3-aminopropyl)-piperazine are dissolved in 30 ml of toluene and according to process alternative (a) mixed with stirring with a mixture of 4.6 g (0.029 mol) of methyl 3-isocyanatoisovalerate and 20 ml of toluene. The mixture is heated for 30 minutes to approximately 70° C., evaporated to dryness under reduced pressure and the oily residue rubbed after the addition of diethyl ether. The methyl 3-(1-diphenylmethylpiperazin-4-ylpropylureido)-isovalerate thus obtained is pure according to its thin-layer chromatogram. ##STR20## Yield: 9.8 g (72% of theory).

Aufarbeitung

  1. additionmixed
  2. temperatureThe mixture is heated for 30 minutes to approximately 70° C.
  3. customevaporated to dryness under reduced pressure
  4. additionafter the addition of diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-ae1d5e2c509c4b00829e0d933bec1b77
Quelldatensatz
uspto-grants-1980_08
Patentnummer
US04216216

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