4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 3048906, Verbindung
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]1[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=1.[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH2:27]>>[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][NH:27][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[CH:13][N:12]=1Komponenten
3
Versuchsvorschrift
An intimate mixture of 5-(2-pyridylmethyl)-2-methylthio-4-pyrimidone (4.7 g) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (3.4 g) was heated at 130°-135° for 7 hours. The cooled residue was triturated with hot water to give 2-[2-(5-methyl-4-imidazolylmethythio)ethylamino]-5-(2-pyridylmethyl)-4-pyrimidone and this product was treated with dilue ethanolic HCl to give the title compound m.p. 207°-210° (aqueous ethanol)
Aufarbeitung
- temperaturewas heated at 130°-135° for 7 hours
- customThe cooled residue was triturated with hot water