Benzylamine → HCID 23347165, Verbindung

HRID 1855959

Reaktionsgleichung

Reaktionsgleichung von HRID 1855959
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH2:14]Br)[CH2:7][OH:8])[CH3:2].[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(OCC)(=O)C>CC(C)=O>[CH2:16]([NH:23][CH2:14][CH2:13][O:12][C:11]1[CH:10]=[CH:9][C:6]([CH2:7][OH:8])=[CH:5][C:4]=1[O:3][CH2:1][CH3:2])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 3

HCID 7504BenzylamineHCID 8857Ethyl AcetateHCID 543733553-Ethoxy-4-(2-bromoethoxy)benzyl alcohol

Produkt 1

HCID 23347165HCID 23347165, VerbindungAusbeute 74,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 27.5 g of 3-ethoxy-4-(2-bromoethoxy)benzyl alcohol and 53.5 g of benzylamine was heated to 130°-135° C. for 1.5 hours with stirring. After cooling the reaction mixture, 300 ml of ethyl acetate was added therein and the mixture was washed twice each time with 50 ml of water, dried with anhydrous sodium sulfate and distilled under reduced pressure to provide an orange oily product. To the product was added 50 ml of acetone to form crystals, which were recovered by filtration under suction to provide 22.5 g of N-benzyl-2-(2-ethoxy-4-hydroxymethylphenoxy)ethylamine having a melting point of 164°-167° C.

Aufarbeitung

  1. temperaturewas heated to 130°-135° C. for 1.5 hours
  2. additionwas added
  3. washthe mixture was washed twice each time with 50 ml of water
  4. dry with materialdried with anhydrous sodium sulfate
  5. distillationdistilled under reduced pressure
  6. customto provide an orange oily product
  7. customto form crystals, which
  8. filtrationwere recovered by filtration under suction

Quellen und Nachweise

ORD-Eintrag
ord-5c7d3d64f88c419b8bca76ac44892cca
Quelldatensatz
uspto-grants-1980_08
Patentnummer
US04217305

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