Hexane → alpha-(Cyclohexyl)-alpha,alpha-bis[2-(diisopropylamino)ethyl]acetamide

HRID 1855974Notizen

Reaktionsgleichung

[CH:1]([N:4]([CH:26]([CH3:28])[CH3:27])[CH2:5][CH2:6][C:7]([CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:8]([NH2:10])=[O:9])([CH3:3])[CH3:2].[H][H].CCCCCC>C(O)C.C(Cl)Cl.[Ru](=O)=O>[CH:11]1([C:7]([CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH:26]([CH3:28])[CH3:27])([CH2:17][CH2:18][N:19]([CH:20]([CH3:22])[CH3:21])[CH:23]([CH3:24])[CH3:25])[C:8]([NH2:10])=[O:9])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Komponenten

Reaktionsbedingungen

Temperatur: 125 °C

Versuchsvorschrift

10 Parts of α,α-bis[2-(diisopropylamino)ethyl]-α-phenylacetamide is dissolved in 130 parts by volume of ethanol and the solution placed in pressure shaker with 1 part of ruthenium dioxide. Hydrogen is introduced at 1000 psi and the reaction mixture heated at about 125° C. and shaken for about 24 hours. Then, the reaction mixture is cooled to room temperature and filtered. The filtrate is stripped of solvent to give an oil. This oil is dissolved in methylene chloride, then hexane added to the solution, methylene chloride evaporated, and the hexane mixture cooled to give α-(cyclohexyl)-α,α-bis[2-(diisopropylamino)ethyl]acetamide, as a crystal solid melting at about 114°-115° C. This compound has the following structural formula ##STR49##

Aufarbeitung

temperatureThen, the reaction mixture is cooled to room temperature
filtrationfiltered
customto give an oil
customevaporated
temperaturethe hexane mixture cooled

Quellen und Nachweise

ORD-Eintrag: ord-123a16f7f1c3485f89dc95d12ea3e4ae
Quelldatensatz: uspto-grants-1980_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04217306

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