Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride

HRID 1856260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1856260
[C:1]1([CH2:7][CH2:8][C:9]2[C:10](=[O:16])[NH:11][C:12](=S)[NH:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(CCC2C(=O)NC(SC)=NC=2)C=CC=CC=1.N1C=CC=NC1=O.[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH2:51].[ClH:52]>>[ClH:52].[ClH:52].[CH3:41][C:42]1[NH:46][CH:45]=[N:44][C:43]=1[CH2:47][S:48][CH2:49][CH2:50][NH:51][C:12]1[NH:11][C:10](=[O:16])[C:9]([CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:14][N:13]=1

Komponenten

6

Edukt 5

HCID 313Hydrochloric AcidHCID 684012(1H)-PyrimidinoneHCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 129459715-(2-Phenylethyl)-2-thiouracilHCID 129515085-Phenylethyl-2-methylthio-4-pyrimidone

Produkt 1

HCID 233461712-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride

Versuchsvorschrift

5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.5) with 2-(5-methyl-4-imidazolylmethylthio)ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2 N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.

Aufarbeitung

  1. customgave an oil which
  2. customthe solution evaporated to dryness
  3. customthe residue recrystallised from methanol

Quellen und Nachweise

ORD-Eintrag
ord-33d07fdff70d438db3e0a3c9177ae667
Quelldatensatz
uspto-grants-1980_08
Patentnummer
US04218452

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