Hydrochloric Acid → HCID 54470793, Verbindung

HRID 1856908Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1856908
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[NH2:21])[CH:16]=O.Cl>CO>[Cl:12][C:13]1[CH:14]=[C:15]([CH:16]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:18]=[CH:19][C:20]=1[NH2:21]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 2357176-Hydroxy-3-coumaranoneHCID 132977934-Amino-3-chlorobenzaldehyde

Produkt 1

HCID 54470793HCID 54470793, VerbindungAusbeute 91,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-chloro-4-aminobenzaldehyde 1.24 g were dissolved in methanol 75 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure to obtain the desired compound 1.75 g.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for five hours under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fe3ce813370f4afaa58b335c7cf54d54
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06143779

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