Methyl 2-amino-4-chloro-5-iodobenzoate → 4-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

HRID 1857630

Reaktionsgleichung

Reaktionsgleichung von HRID 1857630
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH2:12].[CH3:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](Cl)=[O:24])[CH:18]=[C:19]([CH3:21])[CH:20]=1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][C:23](=[O:24])[CH2:22][C:17]1[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[CH:18]=1

Komponenten

3

Edukt 2

HCID 10852539Methyl 2-amino-4-chloro-5-iodobenzoateHCID 15895699(3,5-Dimethylphenyl)acetyl chloride

Produkt 1

HCID 540909164-Chloro-2-[2-(3,5-dimethylphenyl)-acetylamino]-5-iodo-benzoic acid methyl ester

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To a solution of 2-amino-4-chloro-5-iodo-benzoic acid methyl ester (2.26 g in 25 mL dichloroethane) was added (3,5-dimethylphenyl) acetyl chloride (1.2 g in 15 mL dichloroethane) and the mixture heated to 75° C. on an oil bath. After 3 hours, the reaction was cooled and the solvent removed in vacuo. The title compound was isolated by crystallization from methanol (2.7 g).

Aufarbeitung

  1. temperaturethe reaction was cooled
  2. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-135bf16af6e24199a6363aebf26854a5
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06147088

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