Hydrochloric Acid → (5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

HRID 18579

Reaktionsgleichung

Reaktionsgleichung von HRID 18579
Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[O:5][N:4]=1.C1N2CN3CN(C2)C[N:15]1C3.Cl>CCO>[Cl:13][C:10]1[S:9][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][NH2:15])[CH:7]=2)=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 4101HexamethylenetetramineHCID 111501463-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

Produkt 1

HCID 68616593(5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1.00 g (3.59 mmol) 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole and 503.3 mg (3.59 mmol) urotropin were dissolved in 40 mL EtOH. The reaction mixture was stirred at room temperature for 16 h. The next day 3 mL of a conc. HCl-solution were added and the resulting mixture was refluxed for 45 minutes. After cooling the precipitate was filtered off and washed with water. The white crystalline material was dried under reduced pressure at 40° C.

Aufarbeitung

  1. temperaturethe resulting mixture was refluxed for 45 minutes
  2. temperatureAfter cooling the precipitate
  3. filtrationwas filtered off
  4. washwashed with water
  5. customThe white crystalline material was dried under reduced pressure at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-5a6c7457cfdb4e10b5a9e271bd261c05
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741341B2

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