Acetyl chloride → 1-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

HRID 1857968Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1857968
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[CH3:13].[Cl-].[Al+3].[Cl-].[Cl-]>Cl>[CH3:13][C:7]1[CH:8]=[C:9]([C:1]([CH3:2])=[O:3])[C:10]([F:12])=[CH:11][C:6]=1[Cl:5]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 967472-Chloro-4-fluorotolueneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 27365641-(4-Chloro-2-fluoro-5-methylphenyl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

At 60° C., 157 g of acetyl chloride were added dropwise to a mixture of 250 g of 2-chloro-4-fluorotoluene and 267 g of aluminum chloride. The reaction mixture was stirred at 120° C. for 2 hours and then, while still at 100° C., poured onto 2 l of an ice/water mixture. 180 ml of concentrated hydrochloric acid were subsequently stirred into the resulting mixture. The product was then extracted using three times 200 ml of dichloromethane. The organic phase was then washed with 200 ml of water, dried over sodium sulfate and finally concentrated. Yield: 290 g; oil.

Aufarbeitung

  1. extractionThe product was then extracted
  2. washThe organic phase was then washed with 200 ml of water
  3. dry with materialdried over sodium sulfate
  4. concentrationfinally concentrated

Quellen und Nachweise

ORD-Eintrag
ord-56e843515cb84acab58e1c2333dc5328
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06150303

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