Trifluoroacetic acid → 1-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1,2-dihydroquinolin-6-yl]-3-pyridin-4-yl-urea

HRID 1858169Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1858169
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][O:16][C:17]1[C:26]2[C:21](=[CH:22][C:23]([Cl:37])=[C:24]([NH:27][C:28]([NH:30][C:31]3[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=3)=[O:29])[CH:25]=2)[NH:20][C:19](=[O:38])[C:18]=1[C:39]1[S:40][CH:41]=[CH:42][CH:43]=1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:37][C:23]1[CH:22]=[C:21]2[C:26]([C:17]([O:16][CH2:15][CH2:14][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[C:18]([C:39]3[S:40][CH:41]=[CH:42][CH:43]=3)[C:19](=[O:38])[NH:20]2)=[CH:25][C:24]=1[NH:27][C:28]([NH:30][C:31]1[CH:32]=[CH:33][N:34]=[CH:35][CH:36]=1)=[O:29]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 539673912-{2-[7-Chloro-2-oxo-6-(3-pyridin-4-yl-ureido)-3-thiophen-2-yl-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 98496751-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1,2-dihydroquinolin-6-yl]-3-pyridin-4-yl-urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2-{2-[7-chloro-2-oxo-6-(3-pyridin-4-yl-ureido)-3-thiophen-2-yl-1,2-dihydroquinolin-4-yloxy]-ethyl }-piperidine-1-carboxylic acid tert-butyl ester in methylene chloride is added trifluoroacetic acid and the mixture stirred at room temperature. After 30 minutes, the mixture is concentrated in vacuo, resolvated in 10% ammonium hydroxide in methanol and concentrated once again. Purification by flash chromatography on silica gel gives the title compound.

Aufarbeitung

  1. concentrationthe mixture is concentrated in vacuo
  2. concentrationconcentrated once again
  3. customPurification by flash chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-496efc17784e42e4a1bcfdcaae4297e6
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06150522

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