4-Methylisoquinoline-5-sulfonyl chloride → HCID 70275386, Verbindung

HRID 1858918Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1858918
C(OC([N:8]1[CH2:13][C@H:12]([CH3:14])[NH:11][CH2:10][C@@H:9]1[CH3:15])=O)(C)(C)C.[Cl:16][S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:19])=[O:18]>>[ClH:16].[ClH:16].[CH3:15][C@H:9]1[CH2:10][NH:11][C@@H:12]([CH3:14])[CH2:13][N:8]1[S:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[C:22]([CH3:30])=[CH:23][N:24]=[CH:25]2)(=[O:18])=[O:19]

Komponenten

3

Edukt 2

HCID 154871104-Methylisoquinoline-5-sulfonyl chlorideHCID 24903577tert-Butyl (2S,5S)-2,5-dimethylpiperazine-1-carboxylate

Produkt 1

HCID 70275386HCID 70275386, VerbindungAusbeute 51,3 %

Versuchsvorschrift

Using 0.43 g of cis-1-(tert-butoxycarbonyl)-2,5-dimethylpiperazine and 0.48 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.2 g of the objective compound (white crystals).

Quellen und Nachweise

ORD-Eintrag
ord-9de509a29d4f4a9bb5a050d09dabb6d3
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153608

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