Pyrrole-2-carboxaldehyde → (Z)-1,3-Dihydro-4-fluoro-5-nitro-3-[(1H-pyrrol-2-yl)methylene]-2H-indol-2-one

HRID 1859065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859065
[F:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:14])[NH:6]2.[NH:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[CH:20]=O.[OH-].C([N+](CCCC)(CCCC)CCCC)CCC>CO>[F:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]2[C:3]=1/[C:4](=[CH:20]/[C:16]1[NH:15][CH:19]=[CH:18][CH:17]=1)/[C:5](=[O:14])[NH:6]2

Komponenten

5

Edukt 3

HCID 13854Pyrrole-2-carboxaldehydeHCID 2723671Tetrabutylammonium HydroxideHCID 155126004-Fluoro-5-nitroindolin-2-one2×

Produkt 1

HCID 21253427(Z)-1,3-Dihydro-4-fluoro-5-nitro-3-[(1H-pyrrol-2-yl)methylene]-2H-indol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1,3-dihydro-4-fluoro-5-nitro-2H-indol-2-one (400 mg, 2.04 mmol) (Starting Material 10) in MeOH (4 mL), was successively added at room temperature pyrrole-2-carboxaldehyde (220 mg, 2.25 mmol) (Aldrich) and tetrabutyl ammonium hydroxide (4.5 mL, 1.0 M solution in MeOH)(Aldrich). The mixture was stirred at r.t. for 12 h, then quenched with 1N HCl. The yellow precipitate was collected by suction filtration, washed with water and dried in a vacuum oven. (Yield 510 mg,92%).

Aufarbeitung

  1. customquenched with 1N HCl
  2. filtrationThe yellow precipitate was collected by suction filtration
  3. washwashed with water
  4. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-3ff0a546d01c4f4d8abb9461ed49e5d5
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153634

Notizen zur Reaktion

Wird geladen…