Methyl iodide → Docosahexaenoyl choline iodide

HRID 1859091Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859091
[C:1]([O:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[I:30][CH3:31]>C(Cl)Cl>[I-:30].[C:1]([O:24][CH2:25][CH2:26][N+:27]([CH3:31])([CH3:29])[CH3:28])(=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 543902942-Dimethylaminoethyl docosahexaenoate

Produkt 1

HCID 86754749Docosahexaenoyl choline iodideAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2-dimethylaminoethyl docosahexaenoate (1.12 g, 2.80 mmol) in CH2Cl2 (10.0 mL) was added iodomethane (0.80 g, 5.60 mmol) dropwise at room temperature. The mixture was stirred at room temperature for 3 hr. The solvent and excess reagent was removed under reduced pressure and the residue was triturated with hexanes. The mixture was centrifuged and the supernatant was removed. The residue was dried under reduced pressure to provide the product, docosahexaenoyl choline iodide (1.46 g, 96%), as an off white solid.

Aufarbeitung

  1. customThe solvent and excess reagent was removed under reduced pressure
  2. customthe residue was triturated with hexanes
  3. customthe supernatant was removed
  4. customThe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a293ad9e71d64e2fa7d40639b215f019
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153653

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