Methanol → Methyl 2-(2-(aminomethyl)phenyl)acetate hydrochloride

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Reaktionsgleichung

Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([OH:13])=[O:12].S(Cl)([Cl:16])=O.[CH3:18]O>>[ClH:16].[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([O:13][CH3:18])=[O:12]

Komponenten

Edukt 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 57434972-(Aminomethyl)phenylacetic acid hydrochloride

Produkt 1

HCID 21185367Methyl 2-(2-(aminomethyl)phenyl)acetate hydrochloride

Versuchsvorschrift

2-(Aminomethyl)-benzeneacetate hydrochloride was stirred in dry methanol. Thionyl chloride (1.1 eq.) was added dropwise and the mixture was stirred at room temperature overnight to provide for (methyl 2-(aminomethyl)-benzeneacetate hydrochloride as a white solid.

Quellen und Nachweise

ORD-Eintrag: ord-7c6b8b5252994161a81cc7cfc6a05970
Quelldatensatz: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06153652

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