Phosphate → 6-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

HRID 1859551

Reaktionsgleichung

Reaktionsgleichung von HRID 1859551
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([S:21]C#N)=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([SH:21])=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 1061PhosphateHCID 446094D-1,4-DithiothreitolHCID 543438496-tert-Butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

Produkt 1

HCID 540779236-tert-Butyl-5-mercapto-2,3-dihydro-indole-1-carboxylic Acid Tert-Butyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The title compound was prepared according to General Method 14 using 6-tert-butyl-5-thiocyanato-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (prepared in Example KK; 2.0 g, 6.6 mmol), dithiothreitol (1.21 g, 7.9 mmol), EtOH (100 mL), and phosphate buffer (pH: 7.5. 10 mL). The crude product was used without any purification.

Aufarbeitung

  1. customThe crude product was used without any purification

Quellen und Nachweise

ORD-Eintrag
ord-12e5dedeed054aff8668116be47d6a70
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528510B1

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