Sodium Hydroxide → HCID 10412670, Verbindung

HRID 1859872Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859872
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:26][CH:25]=2)=[O:23])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[O:36][CH3:37])=[CH:28][CH:29]=2)=[O:23])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 18625856Ethyl 2-butyl-3-[4-[2-(2'-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate

Produkt 1

HCID 10412670HCID 10412670, VerbindungAusbeute 88,2 %

Versuchsvorschrift

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[2-(2′-methoxybiphenyl-4-carbonylamino)ethoxy]phenyl]propionate (750 mg), which is the product of Example 42, was reacted with aqueous sodium hydroxide solution (1N, 5.00 ml) and the reaction mixture was treated to give the title compound (625 mg) as a pale orange powder.

Aufarbeitung

  1. additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag
ord-97c3b30546c544389ac699f3cada0a0c
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528525B1

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