Sodium Hydroxide → 2-Butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionic acid

HRID 1859881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859881
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:36])[C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[CH:26][CH:25]=2)=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 18626012Ethyl 2-butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionate

Produkt 1

HCID 99817062-Butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionic acidAusbeute 77,1 %

Versuchsvorschrift

In a similar manner to that described in Example 2, ethyl 2-butyl-3-[4-[3-(4-pyridine-2-ylbenzoylamino)propoxy]phenyl]propionate (161 mg), which is the product of Example 69, was reacted with aqueous sodium hydroxide solution (1N, 1.20 ml) and the reaction mixture was treated to give the title compound (117 mg) as a white powder.

Aufarbeitung

  1. additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag
ord-781583326a514a719623b541cdccc6de
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528525B1

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