Sodium Hydroxide → 2-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acid

HRID 1859913Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1859913
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:44]=[CH:43][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1.[OH-].[Na+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([O:11][CH:12]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28][C:29](=[O:42])[C:30]3[CH:35]=[CH:34][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=4)=[CH:32][CH:31]=3)=[CH:21][CH:20]=2)[C:13]([OH:15])=[O:14])=[CH:43][CH:44]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 18625869HCID 18625869, Verbindung

Produkt 1

HCID 177956632-(4-Pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionic acidAusbeute 81,9 %

Versuchsvorschrift

In a similar manner to that described in Example 2, ethyl 2-(4-pyridine-2-ylphenoxy)-3-[4-[2-(4-pyridine-2-ylbenzoylamino)ethoxy]phenyl]propionate (500 mg), which is the product of Example 134, was reacted with aqueous sodium hydroxide solution (1N, 2.00 ml) and the reaction mixture was treated to give the title compound (390 mg) as a white powder.

Aufarbeitung

  1. additionthe reaction mixture was treated

Quellen und Nachweise

ORD-Eintrag
ord-a5ed063452a64d8283ca7417074e45ab
Quelldatensatz
uspto-grants-2003_03
Patentnummer
US06528525B1

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