Potassium Hydroxide → 3-(4-Hydroxyphenyl)-2-(4-isopropylphenoxy)propionic acid
Reaktionsgleichung
OC1C=CC([C:8]([O:19][C:20]2[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=2)([C:14](OCC)=O)[C:9]([O:11]CC)=[O:10])=CC=1.[OH-:29].[K+]>>[OH:29][C:20]1[CH:25]=[CH:24][C:23]([CH2:14][CH:8]([O:19][C:20]2[CH:21]=[CH:22][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:24][CH:25]=2)[C:9]([OH:11])=[O:10])=[CH:22][CH:21]=1Komponenten
3
Versuchsvorschrift
In a similar manner to that described in Reference example 2(b), a reaction was carried out using diethyl 2-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)malonate (25.2 g), which is the product of Reference example 5(c), and potassium hydroxide (20.0 g) and the reaction mixture was treated to afford, via crystals of 3-(4-hydroxyphenyl)-2-(4-isopropylphenoxy)propionic acid, the desired compound (19.8 g) as a syrup.
Aufarbeitung
- additionthe reaction mixture was treated